Literature summary extracted from

Yamamoto, H.; Vinitketkumnuen, A.; Adachi, Y.; Taniguchi, H.; Hirata, T.; Miyamoto, N.; Nosho, K.; Imsumran, A.; Fujita, M.; Hosokawa, M.; Hinoda, Y.; Imai, K.
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma (2004), Carcinogenesis, 25, 2353-2360.

Application

EC Number	Application	Comment	Organism
3.4.24.B7	medicine	expression of matrilysin-2 is significantly correlated with nuclear beta-catenin expression and MMP-9 expression. Patients with matrilysin-2-positive cancer have significantly shorter overall and disease-free survival periods than those with matrilysin-2 negative cancer. Matrilysin-2 expression retains its significant predictive value for overall and disease-free survival in multivariate analysis. Patients with concomitant expression of matrilysin-2 and MMP-9 have the worst prognosis	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B7	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.B7	esophageal squamous cell carcinoma cell	overexpression in 24 of the 50 esophageal squamous cell carcinoma tissues. Overexpression is significantly correlated with depth of invasion, lymph node metastasis amd an advance in pathological tumor node metastasis stage	Homo sapiens	-
3.4.24.B7	additional information	matrilysin-2 mRNA expression is undetectable or only faintly detected in non-tumor tissues	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B7	matrilysin-2	-	Homo sapiens
3.4.24.B7	MMP-26	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)